Welcome Dr. Olexandr Isayev, a new faculty member of MBSB!

The Isayev lab works at the interface of theoretical chemistry, pharmaceutical sciences, and artificial intelligence (AI).

Read more about Dr. Isayev here.

Dr. Isayev said that “We are working towards the acceleration of molecular discovery and design, in particular of kinase inhibitors. We also focus on both generative and predictive machine learning models for chemical and biological data and the automation of scientific experimentation”.






Congratulations to Dr. Gronenborn!

She will receive the 2021 Founders Award of Biophysics Society.

Read more HERE.





Welcome Dr. Jonathan Coleman, a new faculty member of MBSB!!

Jonathan received his B.Sc. in Biochemistry and Molecular Biology from the University of British Columbia and his Ph.D. in the lab of Dr. Robert Molday. In 2013, he joined the Eric Gouaux's lab at Oregon Health & Science University as a postdoctoral fellow. In May 2020, he became an assistant professor in the Department of Structural Biology at the University of Pittsburgh.


The aim of his research is to elucidate the molecular function, architecture, and high-affinity drug binding sites of synaptic vesicle transporters in neurons by studying their function using biochemical techniques and determining their structures using single particle cryo-EM. He is particularly interested in understanding the conformational changes and mechanism associated with transport. He has developed methods for large-scale expression, stabilization by drugs, and for the production of antibodies which recognize these transporters. The use of transporter-antibody complexes is essential in order to provide mass and molecular features to assist in cryo-EM reconstructions because these transporters are small membrane proteins which are largely ensconced within membrane. Atomic structures of transporters in complex with therapeutic drugs are essential for the design of better small-molecule therapeutics with higher specificity and fewer side-effects and will also advance efforts toward understanding the function of these transporters.






Ms. Lisa Clark passed her oral defense earlier this week and completed her Ph.D. degree.  Lisa carried out dissertation research with Prof. Jean-Pierre Vilardaga in the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine.  The title of her dissertation talk was “Structural mechanisms of class B GPCR signaling: the case of the parathyroid hormone receptor ”. Approximately 40 colleagues and friends remotely listened to her talk.  



Congratulations, Lisa!!



Welcome Dr. Ulrike Endesfelder, a new faculty member of MBSB!!

Ulrike Endesfelder received her diploma in physics from the University of Bonn in 2008. Afterwards she became interested in the world of molecular machines and spent a research stay at the Waseda University in Tokyo. In 2012 she received her PhD in Biophysics from the University of Bielefeld and performed her postdoctoral trainings from 2012-2014 at the University of Würzburg and the University of Frankfurt. In October 2014, she moved to the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, where she led a research group combining methods from physics and biology to understand the molecular organization and behavior of microbial cell biology. In 2020 she joined CMU as Associate Professor of Experimental Biophysics and became part of the MBSB program.

She commented us,

 “Interested students can choose from several research projects on one or more of the following topics: single molecule imaging, super resolution microscopy, microbial cell biology and biomolecular laboratory work, high throughput analysis of large data sets and/or microscopy hardware and software design. Our interdisciplinary research group consists of biologists, chemists, physicists and computer scientists, so that we can tailor research projects to the individual interests and experience of our students.”

This is an exciting research opportunity!!