Aryal earns Ph.D
Mr. Manish Aryal successfully passed his oral defense on December 15th, and completed his Ph.D. degree. The title of his dissertation project is, “Molecular Mechanism of Bruton’s Tyrosine Kinase Activation by the HIV-1 Nef Virulence Factor”. His supervisor Dr. Smithgall told that Manish had brilliant ideas that made a breakthrough of his project. Over 30 people attended his thesis presentation remotely and enjoyed his presentation.
Lavrenyuk earns Ph.D
Mr. Kirill Lavrenyuk successfully passed his oral defense on December 8th, and completed his Ph.D. degree. The title of his dissertation project is, “Quantifying Mechanical Behavior and Coherence of Epithelial Cell Monolayers”. His supervisor Dr Kris Dahl introduced that Kirill is a smart student, who has outstanding productivity, creativity, and a leadership. Approximately 30 people attended his thesis presentation remotely and enjoyed his presentation.
Kirill Lavrenyuk Published
A talented MBSB student, Kirill Lavrenyuk, published his first-author review, “Imaging methods in mechanosensing: a historical perspective and visions for the future,” Mol Biol Cell. 2021, 32(9):842-854. (doi: 10.1091/mbc.E20-10-0671). In this work, he discusses the recent history of mechanobiology over the past 25 years and highlights the emerging technologies and theories that are driving the field forward. To fully understand the mechanical nature of biological systems, recent technologies have pushed the limit of what is observable, from protein-protein interactions, to cell-cell, and even whole tissue mechanics.
In another recent work, “A single stiffened nucleus alters cell dynamics and coherence in a monolayer”, Cytoskeleton. 2021 (doi: 10.1002/cm.21660) Kirill worked with a talented team from Institute for Systems and Robotics in Portugal to develop a new methodology to measure collective cell behavior within monolayers. By comparing healthy nuclei to those overexpressing a Lamin-A mutant found in Hutchinson-Gilford Progeria Syndrome (HGPS), they showed that cellular migration within a monolayer is substantially altered in cells neighboring the HGPS Lamin-A expressing-cells.
It is Graduate program recruitment season!!
MBSB will have a booth at the virtual Graduate Fair, hosted by the Biophysics Society.
Date: Nov 11 and 12, 2021
This event is free for students!
We are seeking prospective students who are highly motivated to pursue biophysical and structural biology studies. We would appreciate if you could forward the information of our program and the virtual fair to students who have a strong interest in biophysics graduate programs.
Congrats to Ari!
August 9th, 2021
Congratulations to Ari!
Mr. Ari Selzer, a 3rd year PhD student in Dr. Tom Smithgall’s lab in the MBSB program, received an NIH F31 Ruth Kirschstein predoctoral fellowship from the National Cancer Institute. Ari’s research project is centered on developing and characterizing small molecule allosteric regulators of Src-Family Kinases as drug candidates for acute myeloid leukemia. Ari’s project incorporates structural determination of small molecule-kinase complexes along with biophysical and cellular experiments to understand the mechanism of action of this novel class of drug candidates. Congratulations once again!!