Research Interests: My area of research is using spectroscopy, specifically UV resonance Raman spectroscopy and NMR spectroscopy, to determine the structures of proteins and protein-small molecule complexes that cannot be solved by more “traditional” structural biology methods. I am currently working on two projects. (1) I use spectroscopic methods to characterize the structures of polyglutamine peptides in their solution and fibril forms as they relate to neurodegenerative diseases, such as Huntington’s Disease. (2) I am working to characterize protein-xenon interactions for the development of a protein-based xenon sensor for nuclear activity.
B.S. in Chemical Engineering, North Carolina State University, Raleigh, NC, May 2012
M.S. in Biomanufacturing, North Carolina State University, Raleigh, NC, Aug 2014
PhD Advisor: Dr. Sanford Asher
Department of Chemistry
707 Chevron Science Center
219 Parkman Avenue
Pittsburgh, PA 15260
email: STW59 - AT - pitt.edu
- White SE. Characterization of the Freeze/Thaw Stability of a Cell Culture-Derived Influenza A/PR/8/34 (H1N1) Virus Stock and the Production Impact thereof. Raleigh, NC: North Carolina State University; 2014
Jakubek, R. S.; Handen, J.; White, S. E.; Asher, S. A.; Lednev, I. K. Ultraviolet Resonance Raman Spectroscopic Markers for Protein Structure and Dynamics. TrAC - Trends Anal. Chem. 2018, 103, 223–229.
Jakubek, R. S.; White, S. E.; Asher, S. A. UV Resonance Raman Structural Characterization of an (In)Soluble Polyglutamine Peptide. J. Phys. Chem. B 2019, 123 (8), 1749–1763.
Jakubek, R. S.; Workman, R. J.; White, S.; Asher, S. A. Polyglutamine Solution-State Structural Propensity Is Repeat Length Dependent. J. Phys. Chem. B 2019 123(19), 4193-4203.