Research Interests:   My area of research is using spectroscopy, specifically UV resonance Raman spectroscopy and NMR spectroscopy, to determine the structures of proteins and protein-small molecule complexes that cannot be solved by more “traditional” structural biology methods. I am currently working on two projects. (1) I use spectroscopic methods to characterize the structures of polyglutamine peptides in their solution and fibril forms as they relate to neurodegenerative diseases, such as Huntington’s Disease. (2) I am working to characterize protein-xenon interactions for the development of a protein-based xenon sensor for nuclear activity.

 

 

Education:

B.S. in Chemical Engineering, North Carolina State University, Raleigh, NC, May 2012

M.S. in Biomanufacturing, North Carolina State University, Raleigh, NC, Aug 2014


PhD Advisor: Dr. Andrew Hinck

Lab Address: 

Department of Structural Biology
Room 2024, 3501 Fifth Ave
Pittsburgh, PA 15260

email: STW59 - AT - pitt.edu


Publications:

  • White SE. Characterization of the Freeze/Thaw Stability of a Cell Culture-Derived Influenza A/PR/8/34 (H1N1) Virus Stock and the Production Impact thereof. Raleigh, NC: North Carolina State University; 2014
  • Jakubek, R. S.; Handen, J.; White, S. E.; Asher, S. A.; Lednev, I. K. Ultraviolet Resonance Raman Spectroscopic Markers for Protein Structure and Dynamics. TrAC - Trends Anal. Chem. 2018, 103, 223–229.

  • Jakubek, R. S.; White, S. E.; Asher, S. A. UV Resonance Raman Structural Characterization of an (In)Soluble Polyglutamine Peptide. J. Phys. Chem. B 2019, 123 (8), 1749–1763. 

  • Jakubek, R. S.; Workman, R. J.; White, S.; Asher, S. A. Polyglutamine Solution-State Structural Propensity Is Repeat Length Dependent. J. Phys. Chem. B 2019 123(19), 4193-4203.