The Smithgall lab is focused on studying the roles of Src family kinases in cancers and the accessory protein Nef in HIV infection and pathogenesis. My research is focused on Src family kinases which are key members of nearly all signalling pathways in the human body and are characterized by their regulatory SH3 and SH2 domains N-terminal of the kinase domain. I use a combination of biochemical methods such as surface plasmon resonance and kinase assays with X-ray crystallography to investigate the mechanism of small molecule regulators of specific Src family kinases.
B.S. Biochemistry, Northeastern University, 2018
PhD Advisor: Dr. Thomas E. Smithgall
Bridgeside Point II Room 533
100 Technology Dr
Pittsburgh, PA 15219
email: ARS289 [at] pitt.edu