MBSB Students Present Research at the ASBMB Conference in Seattle!
Ari Selzer and Giancarlo Gonzalez-Ariezega, MBSB students in the Smithgall laboratory, recently presented their research findings at the annual meeting of the American Society for Biochemistry and Molecular Biology (Discover BMB, March 25-28, 2023, Seattle WA). Ari gave an oral presentation in the spotlight session “Protein synthesis, structure, modifications and interactions” entitled “Small Molecule Allosteric Modulators of the AML-associated Src-family Kinase, Hck.” This talk was focused on his thesis project which utilizes various biochemical and biophysical techniques to demonstrate how small molecules can bind allosterically to the Src-family kinase Hck and regulate its natural intramolecular control of kinase activity. In related work, Giancarlo presented a poster demonstrating that genetic enhancement of intramolecular interactions regulating Src-family kinase activity sensitizes the kinase domain to ATP-site inhibitor action.
You can find the Smithgall’s lab web site and the students’ research interest site below.