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MBSB Students Present Research at the ASBMB Conference in Seattle!

Ari Selzer and Giancarlo Gonzalez-Ariezega, MBSB students in the Smithgall laboratory, recently presented their research findings at the annual meeting of the American Society for Biochemistry and Molecular Biology (Discover BMB, March 25-28, 2023, Seattle WA).  Ari gave an oral presentation in the spotlight session “Protein synthesis, structure, modifications and interactions” entitled “Small Molecule Allosteric Modulators of the AML-associated Src-family Kinase, Hck.” This talk was focused on his thesis project which utilizes various biochemical and biophysical techniques to demonstrate how small molecules can bind allosterically to the  Src-family kinase Hck and regulate its natural intramolecular control of kinase activity. In related work, Giancarlo presented a poster demonstrating that genetic enhancement of intramolecular interactions regulating Src-family kinase activity sensitizes the kinase domain to ATP-site inhibitor action.

 

You can find the Smithgall’s lab web site and the students’ research interest site below.

http://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/185-thomas-smithgall

http://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/282-ari-selzer

https://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/286-giancarlo-gonzalez

 

 

By MBSB