Billy Day

Address:
Department of Pharmaceutical Sciences
Department of Chemistry
Department of Environmental & Occupational Health Director, Proteomics Core Labs University of Pittsburgh
10017 BST3
3501 Fifth Avenue
Pittsburgh, PA 15261

Phone: 412-648-9706
Fax: 412-383-7436
Email: bday@pitt.edu
Homepage: Visit

Background:

When and where you received your PhD
1988, University of Oklahoma

Where you did your postdoc
1988-1991, Massachusetts Institute of Technology

Research:
A major focus of the Day lab is the design and synthesis of potential antitumor agents. Other synthetic projects in the lab include preparation of radio- and stable isotope-labeled forms of drugs, toxins and metabolites, as well as (photo)affinity probes for mechanistic studies. Beyond the preparation of libraries of agents, their biological properties are also examined. Additionally, great advantage is taken of the synthetic prowess of outstanding colleagues here at Pitt (e.g., Profs. Curran, Nelson and Wipf); through collaborative testing of libraries that their groups prepare. The Day lab performs a variety of high throughput biochemical and cell-based assays. All of this data is used for development of computational models that are reiterated into drug design schemes. Prof. Day also directs the University's Proteomics Core Lab, which provides mass spectrometric analyses of the protein complement of cells, tissues and organisms. The resulting vast amount of information is useful in disease detection, prevention, control and treatment. Sophisticated experimental design, instrumentation and data analysis tools are used to evaluate the proteome, and the lab collaborates extensively with many groups across the campus.