NMR & computations of protein structures, dynamics, & drug effects


Research in the Tang Group focuses on the structures and dynamics of membrane proteins, which are the primary targets for many classes of drugs. The current research efforts are directed at understanding where and how low-affinity drugs interact with proteins and what structural and dynamical consequences are on these proteins due to drug binding. Both experimental (primarily NMR) and computational (primarily MD simulations) approaches are taken in the investigations. The ultimate goal is to understand the molecular mechanisms of the action of low-affinity drugs and to devise rational designs of safer drugs with minimal side effects.


[PubMed search]

Department of Anesthesiology
Department of Pharmacology and Biological Chemistry
Department of Computational Biology


PhD 1990, State University of New York at Stony Brook

Postdoctoral Training

1990-1993, University of California, Berkeley


Department of Pharmacology & Chemical Biology
University of Pittsburgh 
Room 2049
Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15260

Phone: (412) 624-8783
Fax: (412) 648-8998

E-mail: tangp@anes.upmc.edu 

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