Merkel Cell Polyomavirus
“Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network”
Bizunesh Abere, Hongzhao Zhou, Jinghui Li, Simon Cao, Tuna Toptan, Adam Grundhoff, Nicole Fischer, Patrick S. Moore, Yuan Chang
mBio Dec 2020, 11 (6) e03059-20; DOI: 10.1128/mBio.03059-20
Merkel cell polyomavirus makes a circular RNA as part of a feedback network controlling its own replication by targeting an inhibitory viral miRNA.
Detection of MCV circMCV-T BSJ (red) and early region T antigen transcripts by BaseScope in situ hybridization.
Tristram-Nagle / STEM Contributions
“Dr. Tristram-Nagle is contributing to STEM research”
Dr. Tristram-Nagle is an active Research Professor in the Physics department at Carnegie Mellon University. An article about her STEM research and an interview about her current studies are found at the following site.
From Targets to Therapies
Check out a special issue in the ACS Medicinal Chemistry Letters. Peter Wipf in MBSB co-edited this issue. Prof. Wipf commented “This year, ACS Medicinal Chemistry Letters celebrates its 10th anniversary. To recognize this occasion, we are publishing a Special Issue entitled “Medicinal Chemistry: From Targets to Therapies.” In 2020, the coronavirus SARS-CoV has overtaken the world amidst a global pandemic. Consequently, antiviral research, and vaccine development and production, have been catapulted into the spotlight. In the face of the problem of bacterial resistance, there is a pressing need for enhanced, sustained research on anti-infective agents. At the same time, pharmaceutical treatments in many other fields are still urgently needed. Medicinal Chemistry is called upon to answer gaps and inequalities in addressing public health needs, more than ever on a moment’s notice.”
“Regulating CRISPR/Cas9 Function through Conditional Guide RNA Control”
Wes Brown, a student in the MBSB and member of the Deiters lab in the Department of Chemistry, has recently published a review on conditional control of CRISPR/Cas9 function through modification of the guide RNA (gRNA). They discuss control of gRNAs by light, small molecules, proteins, and oligonucleotides. These designs have unique advantages compared to other approaches and have allowed precise regulation of gene editing and transcription.
By the MBSB
A beautiful night.
“Another beautiful night at #carnegiemellon”
From Prof. Dahl in MBSB