“Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4–S5 linker in activation and slow inactivation.”
An exciting paper from the laboratories of Professor Pei Tang and Professor Yan Xu in the MBSB graduate program, in collaboration with research groups at Temple University, University of Pennsylvania, and Shanghai Jiaotong University, was published in the journal Proceedings of the National Academy of Sciences.
Hasanbasri first-author paper
A talented MBSB student, Zikri Hasanbasri, published his first-author paper, “Cleavage-Resistant Protein Labeling with Hydrophilic Trityl Enables Distance Measurements In-Cell,” in J. Phys. Chem. B 2021, 125, 20, 5265-5274 (doi: 10.1021/acs.jpcb.1c02371). In this work, he developed a new spin-label that can measure ESR-based distance constraints in proteins in-cells. Additionally, the spin-label expanded the methodology for distance measurements at temperatures higher than previously possible.
Microcrystals for CryoEM
“Detection of Microcrystals for CryoEM”
Prof. Guillermo Calero in MBSB develops methods in crystallization.
By the MBSB
The 8th Annual Symposium of the Molecular Biophysics and Structural Biology Graduate Program will be held virtually on Friday, 14 May 2021.
Information and details on registration are here: http://www.mbsb.pitt.edu/index.php/mbsb-symposium-2021.
Registration is required to attend the symposium.
By the MBSB Symposium Committee
Koide Group Video
Research description for Professor Koide’s group of MBSB is available on Youtube: